Loading-induced bone formation is mediated by Wnt1 induction in osteoblast-lineage cells

pubmed: wnt1 2023-01-29


Mechanical loading on the skeleton stimulates bone formation. Although the exact mechanism underlying this process remains unknown, a growing body of evidence indicates that the Wnt signaling pathway is necessary for the skeletal response to loading. Recently, we showed that Wnts produced by osteoblast lineage cells mediate the osteo-anabolic response to tibial loading in adult mice. Here, we report that Wnt1 specifically plays a crucial role in mediating the mechano-adaptive response to...



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Exome ยป pubmed: wnt1



Lisa Y Lawson, Nicole Migotsky, Christopher J Chermside-Scabbo, John T Shuster, Kyu Sang Joeng, Roberto Civitelli, Brendan Lee, Matthew J Silva

Date tagged:

01/29/2023, 01:42

Date published:

08/15/2022, 06:00