R-spondin-3 is an oncogenic driver of poorly differentiated invasive breast cancer

pubmed: wnt1 2023-01-29

Summary:

R-spondins (RSPOs) are influential signaling molecules that promote the Wnt/β-catenin pathway and self-renewal of stem cells. Currently, RSPOs are emerging as clinically relevant oncogenes, being linked to cancer development in multiple organs. Although this has instigated the rapid development and testing of therapeutic antibodies targeting RSPOs, functional evidence that RSPO causally drives cancer has focused primarily on the intestinal tract. Here, we assess the oncogenic capacity of RSPO in...

Link:

https://pubmed.ncbi.nlm.nih.gov/36106661/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=16uwQpOeqFYN8R4TKOtwPy2utpqy9ex2oldalD2yF_fQHv2caq&fc=None&ff=20230129092528&v=2.17.9.post6+86293ac

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Exome » pubmed: wnt1

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Authors:

Eline J Ter Steege, Mandy Boer, Nikki C Timmer, Carola Me Ammerlaan, Ji-Ying Song, Patrick Wb Derksen, John Hilkens, Elvira Rm Bakker

Date tagged:

01/29/2023, 09:25

Date published:

09/15/2022, 06:00