Umbelliferone Inhibits Migration, Invasion and Inflammation of Rheumatoid Arthritis Fibroblast-Like Synoviocytes and Relieves Adjuvant-Induced Arthritis in Rats by Blockade of Wnt/β-Catenin Signaling Pathway

pubmed: wnt1 2023-01-29

Summary:

Umbelliferone (UMB), a natural coumarin compound, has been reported to possess anti-rheumatic effects on rheumatoid arthritis (RA) experimental models, but its potential role of UMB in regulating migration, invasion and inflammation of RA fibroblast-like synoviocytes (FLS) remain unclear. Herein, MTT assay was performed to confirm the non-cytotoxic concentrations (10, 20, and 40[Formula: see text][Formula: see text]M) and the treatment time (24[Formula: see text]h) of UMB on TNF-[Formula: see...

Link:

https://pubmed.ncbi.nlm.nih.gov/35997647/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=16uwQpOeqFYN8R4TKOtwPy2utpqy9ex2oldalD2yF_fQHv2caq&fc=None&ff=20230129113747&v=2.17.9.post6+86293ac

From feeds:

Exome » pubmed: wnt1

Tags:

Authors:

Li Cai, Meng-Yuan Zhou, Shuang Hu, Fang-Yuan Liu, Meng-Qing Wang, Xiao-Hua Wang, Fei Jiang, Xiao-Wen Feng, Xue-Song Liu, Rong Li

Date tagged:

01/29/2023, 11:37

Date published:

08/23/2022, 06:00