Wnt/β-catenin signalling is required for pole-specific chromatin remodeling during planarian regeneration

pubmed: wnt1 2023-01-29


For successful regeneration, the identity of the missing tissue must be specified according to the pre-existing tissue. Planarians are ideal for the study of the mechanisms underlying this process; the same field of cells can regrow a head or a tail according to the missing body part. After amputation, the differential activation of the Wnt/β-catenin signal specifies anterior versus posterior identity. Initially, both wnt1 and notum (Wnt inhibitor) are expressed in all wounds, but 48 hours later...



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Eudald Pascual-Carreras, Marta Marín-Barba, Sergio Castillo-Lara, Pablo Coronel-Córdoba, Marta Silvia Magri, Grant N Wheeler, Jose Luis Gómez-Skarmeta, Josep F Abril, Emili Saló, Teresa Adell

Date tagged:

01/29/2023, 13:59

Date published:

01/18/2023, 06:00