Transcriptomic changes underlying EGFR inhibitor resistance in human and mouse models of basal-like breast cancer

pubmed: wnt1 2023-03-17


The goals of this study were to identify transcriptomic changes that arise in basal-like breast cancer cells during the development of resistance to epidermal growth factor receptor inhibitors (EGFRi) and to identify drugs that are cytotoxic once EGFRi resistance occurs. Human patient-derived xenografts (PDXs) were grown in immunodeficient mice and treated with a set of EGFRi; the EGFRi erlotinib was selected for more expansive in vivo studies. Single-cell RNA sequencing was performed on mammary...


From feeds:

Exome ยป pubmed: wnt1



Narmeen S Rashid, David C Boyd, Amy L Olex, Jacqueline M Grible, Alex K Duong, Mohammad A Alzubi, Julia E Altman, Tess J Leftwich, Aaron D Valentine, Nicole S Hairr, Emily K Zboril, Timothy M Smith, Adam D Pfefferle, Mikhail G Dozmorov, J Chuck Harrell

Date tagged:

03/17/2023, 11:16

Date published:

12/09/2022, 06:00