Wnt1 boosts fracture healing by enhancing bone formation in the fracture callus

Despite considerable improvement in fracture care, 5-10% of all fractures still heal poorly or result in non-union formation. Therefore, there is the urgent need to identify new molecules that can be used to improve bone fracture healing. One activator of the Wnt-signaling cascade, Wnt1, has recently gained attention for its intense osteoanabolic effect on the intact skeleton. The aim of the present study was to investigate whether Wnt1 might be a promising molecule to accelerate fracture...