WISP-2 modulates the induction of inflammatory mediators and cartilage catabolism in chondrocytes

pubmed: wnt1 2023-05-31


Wnt-1 inducible signaling pathway protein 2 (WISP-2/CCN5) is a recently identified adipokine that has been described as an important mediator of canonical Wnt activation in adipogenic precursor cells. In osteoarthritis (OA), the most common form of arthritis, chondrocytes exhibit aberrant and increased production of pro-inflammatory mediators and matrix degrading enzymes such as IL-1β and MMP-13. Although recent evidence suggests a role for Wnt signaling in OA physiopathology, little is known...



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Clara Ruiz-Fernández, María González-Rodríguez, Vanessa Abella, Vera Francisco, Alfonso Cordero-Barreal, Djedjiga Ait Eldjoudi, Yousof Farrag, Jesús Pino, Javier Conde-Aranda, Miguel Ángel González-Gay, Antonio Mera, Ali Mobasheri, Lucía García-Caballero, Marina Gándara-Cortés, Francisca Lago, Morena Scotece, Oreste Gualillo

Date tagged:

05/31/2023, 22:11

Date published:

02/12/2023, 06:00