GCN5 regulates ZBTB16 through acetylation, mediates osteogenic differentiation, and affects orthodontic tooth movement

pubmed: wnt1 2023-05-31


In the process of orthodontic tooth movement (OTM), periodontal ligament fibroblasts (PDLFs) must undergo osteogenic differentiation. OTM increased the expression of Zinc finger and BTB domain-containing 16 (ZBTB16), which is implicated in osteogenic differentiation. Our goal was to investigate the mechanism of PDLF osteogenic differentiation mediated by ZBTB16. The OTM rat model was established, and PDLFs were isolated and exposed to mechanical force. Hematoxylin-eosin staining, Alizarin Red...



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Shu-Man Shi, Ting-Ting Liu, Xue-Qin Wei, Ge-Hong Sun, Lin Yang, Juan-Fang Zhu

Date tagged:

05/31/2023, 23:21

Date published:

02/14/2023, 06:00