Genetic modification of miR-34a enhances efficacy of transplanted human dental pulp stem cells after ischemic stroke

pubmed: wnt1 2023-06-01


Human dental pulp stem cells (hDPSCs) promote recovery after ischemic stroke; however, the therapeutic efficacy is limited by the poor survival of transplanted cells. For in vitro experiments in the present study, we used oxygen-glucose deprivation/reoxygenation in hDPSCs to mimic cell damage induced by ischemia/reperfusion. We found that miRNA-34a-5p (miR-34a) was elevated under oxygen-glucose deprivation/reoxygenation conditions in hDPSCs. Inhibition of miR-34a facilitated the proliferation...


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Exome ยป pubmed: wnt1



Jianfeng Wang, Peibang He, Qi Tian, Yu Luo, Yan He, Chengli Liu, Pian Gong, Yujia Guo, Qingsong Ye, Mingchang Li

Date tagged:

06/01/2023, 00:39

Date published:

03/17/2023, 06:00