Taste papilla cell differentiation requires tongue mesenchyme via ALK3-BMP signaling to regulate the production of secretory proteins

pubmed: wnt1 2023-06-01

Summary:

Taste papillae are specialized organs each of which is comprised of an epithelial wall hosting taste buds and a core of mesenchymal tissue. In the present study, we report that during the early stages of embryonic development, bone morphogenetic protein (BMP) signaling mediated by type 1 receptor ALK3 in the tongue mesenchyme is required for the epithelial Wnt/β-catenin activity and taste papilla cell differentiation. Mesenchyme-specific knockout ( cKO ) of Alk3 using Wnt1-Cre and Sox10-Cre...

Link:

https://pubmed.ncbi.nlm.nih.gov/37066397/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=16uwQpOeqFYN8R4TKOtwPy2utpqy9ex2oldalD2yF_fQHv2caq&fc=None&ff=20230601014330&v=2.17.9.post6+86293ac

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Exome » pubmed: wnt1

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Authors:

Mohamed Ishan, Zhonghou Wang, Peng Zhao, Yao Yao, Steven Stice, Lance Wells, Yuji Mishina, Hong-Xiang Liu

Date tagged:

06/01/2023, 01:43

Date published:

04/17/2023, 06:00