The ADAM9/WISP-1 axis cooperates with osteoblasts to stimulate primary prostate tumor growth and metastasis

pubmed: wnt1 2023-06-01


Background: Metastatic prostate cancer (PCa) predicts a poor prognosis and lower likelihood of survival. Osteoblasts (OBs) are known to be responsible for the synthesis and mineralization of bone, although it is unclear as to whether PCa in the prostate gland cooperates with OBs in bone to promote PCa malignant transformation. We aimed to elucidate how primary PCa cells cooperate with distal OBs and contribute to the vicious cycle that leads to metastatic PCa. Methods: N-cadherin, E-cadherin,...


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Exome ยป pubmed: wnt1



An-Chen Chang, Liang-Wei Lin, Yen-Chen Chen, Po-Chun Chen, Shan-Chi Liu, Huai-Ching Tai, Hsi-Chin Wu, Shian-Ying Sung, Tien-Huang Lin, Chih-Hsin Tang

Date tagged:

06/01/2023, 02:41

Date published:

02/13/2023, 06:00