Simvastatin Improves Benign Prostatic Hyperplasia: Role of Peroxisome-Proliferator-Activated Receptor-γ and Classic WNT/β-Catenin Pathway

pubmed: wnt1 2023-06-01


Benign prostatic hyperplasia (BPH) is a common disease in elderly men with an uncertain etiology and mechanistic basis. Metabolic syndrome (MetS) is also a very common illness and is closely related to BPH. Simvastatin (SV) is one of the widely used statins for MetS. Peroxisome-proliferator-activated receptor gamma (PPARγ), crosstalking with the WNT/β-catenin pathway, plays important roles in MetS. Our current study aimed to examine SV-PPARγ-WNT/β-catenin signaling in the development of BPH....


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Zhen Wang, Shu Yang, Yan Li, Yongying Zhou, Daoquan Liu, Jianmin Liu, Michael E DiSanto, Xinhua Zhang

Date tagged:

06/01/2023, 04:11

Date published:

03/11/2023, 06:00