Regulation of morphogen pathways by a Drosophila chondroitin sulfate proteoglycan Windpipe

pubmed: wnt1 2023-06-01


Morphogens provide quantitative and robust signaling systems to achieve stereotypic patterning and morphogenesis. Heparan sulfate (HS) proteoglycans (HSPGs) are key components of such regulatory feedback networks. In Drosophila, HSPGs serve as co-receptors for a number of morphogens, including Hedgehog (Hh), Wingless (Wg), Decapentaplegic (Dpp) and Unpaired (Upd, or Upd1). Recently, Windpipe (Wdp), a chondroitin sulfate (CS) proteoglycan (CSPG), was found to negatively regulate Upd and Hh...


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Exome ยป pubmed: wnt1



Woo Seuk Koh, Collin Knudsen, Tomomi Izumikawa, Eriko Nakato, Kristin Grandt, Akiko Kinoshita-Toyoda, Hidenao Toyoda, Hiroshi Nakato

Date tagged:

06/01/2023, 04:11

Date published:

03/10/2023, 06:00