Directed differentiation of human pluripotent stem cells into articular cartilage reveals effects caused by absence of <em>WISP3</em> , the gene responsible for Progressive Pseudorheumatoid Arthropathy of Childhood

OBJECTIVES: Progressive Pseudorheumatoid Arthropathy of Childhood (PPAC), caused by deficiency of WNT1 inducible signaling pathway protein 3 ( WISP3 ), has been challenging to study because no animal model of the disease exists and cartilage recovered from affected patients is indistinguishable from common end-stage osteoarthritis. Therefore, to gain insights into why precocious articular cartilage failure occurs in this disease, we made in vitro derived articular cartilage using isogenic WISP3...