Prdm6 drives ductus arteriosus closure by promoting ductus arteriosus smooth muscle cell identity and contractility

pubmed: wnt1 2023-06-01

Summary:

Based upon our demonstration that the smooth muscle cell-selective (SMC-selective) putative methyltransferase, Prdm6, interacts with myocardin-related transcription factor-A, we examined Prdm6's role in SMCs in vivo using cell type-specific knockout mouse models. Although SMC-specific depletion of Prdm6 in adult mice was well tolerated, Prdm6 depletion in Wnt1-expressing cells during development resulted in perinatal lethality and a completely penetrant patent ductus arteriosus (DA) phenotype....

Link:

https://pubmed.ncbi.nlm.nih.gov/36749647/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=16uwQpOeqFYN8R4TKOtwPy2utpqy9ex2oldalD2yF_fQHv2caq&fc=None&ff=20230601061204&v=2.17.9.post6+86293ac

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Exome ยป pubmed: wnt1

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Authors:

Meng Zou, Kevin D Mangum, Justin C Magin, Heidi H Cao, Michael T Yarboro, Elaine L Shelton, Joan M Taylor, Jeff Reese, Terrence S Furey, Christopher P Mack

Date tagged:

06/01/2023, 06:12

Date published:

02/07/2023, 06:00