Identifying Rare Genetic Determinants for Improved Polygenic Risk Prediction of Bone Mineral Density and Fracture Risk

pubmed: wnt1 2023-12-03

Summary:

Osteoporosis and fractures severely impact the elderly population. Polygenic risk scores for bone mineral density have demonstrated potential clinical utility. However, the value of rare genetic determinants in risk prediction has not been assessed. With whole-exome sequencing data from 436,824 UK Biobank participants, we assigned White British ancestry individuals into a training data set (n = 317,434) and a test data set (n = 74,825). In the training data set, we developed a common...

Link:

https://pubmed.ncbi.nlm.nih.gov/37830501/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=16uwQpOeqFYN8R4TKOtwPy2utpqy9ex2oldalD2yF_fQHv2caq&fc=None&ff=20231203191616&v=2.17.9.post6+86293ac

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Exome ยป pubmed: wnt1

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Authors:

Tianyuan Lu, Vincenzo Forgetta, Sirui Zhou, J Brent Richards, Celia Mt Greenwood

Date tagged:

12/03/2023, 19:16

Date published:

10/13/2023, 06:00