Sirtuin 6 protects against podocyte injury by blocking the renin-angiotensin system by inhibiting the Wnt1/β-catenin pathway

pubmed: wnt1 2023-12-03


Sirtuins (Sirts) are a family of nicotinamide adenine dinucleotide-dependent protein deacetylases that share diverse cellular functions. Increasing evidence shows that Sirts play a critical role in podocyte injury, which is a major determinant of proteinuria-associated renal disease. Membranous nephropathy (MN) is a typical glomerular disease in which podocyte damage mediates proteinuria development. In this study we investigated the molecular mechanisms underlying the regulatory roles of Sirt...


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Hua Miao, Yan-Ni Wang, Wei Su, Liang Zou, Shou-Gang Zhuang, Xiao-Yong Yu, Fei Liu, Ying-Yong Zhao

Date tagged:

12/03/2023, 20:14

Date published:

08/28/2023, 06:00