Celastrol attenuates diabetic nephropathy by upregulating SIRT1-mediated inhibition of EZH2related wnt/β-catenin signaling

pubmed: wnt1 2023-12-04


Proteinuria is an independent risk factor for the progression of diabetic nephropathy (DN) and an imbalance in podocyte function aggravates proteinuria. Celastrol is the primary active ingredient of T. wilfordii, effective in treating DN renal injury; however, the mechanisms underlying its effect are unclear. We explored how celastrol prevents DN podocyte damage using in vivo and in vitro experiments. We randomly divided 24 male C57BLKS/J mice into three groups: db/m (n = 8), db/db (n = 8), and...



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Exome » pubmed: wnt1



Yuewen Tang, Feng Wan, Xuanli Tang, Yi Lin, Huaqin Zhang, Jiawei Cao, Ruchun Yang

Date tagged:

12/04/2023, 09:06

Date published:

07/16/2023, 06:00