Taste papilla cell differentiation requires the regulation of secretory protein production by ALK3-BMP signaling in the tongue mesenchyme

pubmed: wnt1 2023-12-06


Taste papillae are specialized organs, each of which comprises an epithelial wall hosting taste buds and a core of mesenchymal tissue. In the present study, we report that during early taste papilla development in mouse embryos, bone morphogenetic protein (BMP) signaling mediated by type 1 receptor ALK3 in the tongue mesenchyme is required for epithelial Wnt/β-catenin activity and taste papilla differentiation. Mesenchyme-specific knockout (cKO) of Alk3 using Wnt1-Cre and Sox10-Cre resulted in...



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Mohamed Ishan, Zhonghou Wang, Peng Zhao, Yao Yao, Steven L Stice, Lance Wells, Yuji Mishina, Hong-Xiang Liu

Date tagged:

12/06/2023, 18:12

Date published:

09/08/2023, 06:00