Wg/Wnt1 and Erasp link ER stress to proapoptotic signaling in an autosomal dominant retinitis pigmentosa model

pubmed: wnt1 2023-12-07


The endoplasmic reticulum (ER) is a subcellular organelle essential for cellular homeostasis. Perturbation of ER functions due to various conditions can induce apoptosis. Chronic ER stress has been implicated in a wide range of diseases, including autosomal dominant retinitis pigmentosa (ADRP), which is characterized by age-dependent retinal degeneration caused by mutant rhodopsin alleles. However, the signaling pathways that mediate apoptosis in response to ER stress remain poorly understood....



From feeds:

Exome ยป pubmed: wnt1



Jung-Eun Park, Jiyoun Lee, Soonhyuck Ok, Seunghee Byun, Eun-Ju Chang, Sung-Eun Yoon, Young-Joon Kim, Min-Ji Kang

Date tagged:

12/07/2023, 13:37

Date published:

07/18/2023, 06:00