The USP46 deubiquitylase complex increases Wingless/Wnt signaling strength by stabilizing Arrow/LRP6

pubmed: wnt1 2023-12-07


The control of Wnt receptor abundance is critical for animal development and to prevent tumorigenesis, but the mechanisms that mediate receptor stabilization remain uncertain. We demonstrate that stabilization of the essential Wingless/Wnt receptor Arrow/LRP6 by the evolutionarily conserved Usp46-Uaf1-Wdr20 deubiquitylase complex controls signaling strength in Drosophila. By reducing Arrow ubiquitylation and turnover, the Usp46 complex increases cell surface levels of Arrow and enhances the...


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Exome ยป pubmed: wnt1



Zachary T Spencer, Victoria H Ng, Hassina Benchabane, Ghalia Saad Siddiqui, Deepesh Duwadi, Ben Maines, Jamal M Bryant, Anna Schwarzkopf, Kai Yuan, Sara N Kassel, Anant Mishra, Ashley Pimentel, Andres M Lebensohn, Rajat Rohatgi, Scott A Gerber, David J Robbins, Ethan Lee, Yashi Ahmed

Date tagged:

12/07/2023, 18:43

Date published:

10/05/2023, 06:00