Sirtuin 6 protects against podocyte injury by blocking the renin-angiotensin system by inhibiting the Wnt1/β-catenin pathway

pubmed: wnt1 2023-12-08

Summary:

Sirtuins (Sirts) are a family of nicotinamide adenine dinucleotide-dependent protein deacetylases that share diverse cellular functions. Increasing evidence shows that Sirts play a critical role in podocyte injury, which is a major determinant of proteinuria-associated renal disease. Membranous nephropathy (MN) is a typical glomerular disease in which podocyte damage mediates proteinuria development. In this study we investigated the molecular mechanisms underlying the regulatory roles of Sirt...

Link:

https://pubmed.ncbi.nlm.nih.gov/37640899/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=16uwQpOeqFYN8R4TKOtwPy2utpqy9ex2oldalD2yF_fQHv2caq&fc=None&ff=20231208071819&v=2.17.9.post6+86293ac

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Authors:

Hua Miao, Yan-Ni Wang, Wei Su, Liang Zou, Shou-Gang Zhuang, Xiao-Yong Yu, Fei Liu, Ying-Yong Zhao

Date tagged:

12/08/2023, 07:18

Date published:

08/28/2023, 06:00