Clinical findings of patients with coronavirus disease 2019 in Jiangsu province, China: A retrospective, multi-center study

Type Journal Article Author Rui Huang Author Li Zhu Author Leyang Xue Author Longgen Liu Author Xuebing Yan Author Jian Wang Author Biao Zhang Author Tianmin Xu Author Fang Ji Author Yun Zhao Author Juan Cheng Author Yinling Wang Author Huaping Shao Author Shuqin Hong Author Qi Cao Author Chunyang Li Author Xiang-an Zhao Author Lei Zou Author Dawen Sang Author Haiyan Zhao Author Xinying Guan Author Xiaobing Chen Author Chun Shan Author Juan Xia Author Yuxin Chen Author Xiaomin Yan Author Jie Wei Author Chuanwu Zhu Author Chao Wu URL https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0008280 Volume 14 Issue 5 Pages e0008280 Publication PLOS Neglected Tropical Diseases ISSN 1935-2735 Date 08/05/2020 Extra Publisher: Public Library of Science Journal Abbr PLOS Neglected Tropical Diseases DOI 10.1371/journal.pntd.0008280 Accessed 2020-07-02 14:46:54 Library Catalog PLoS Journals Language en Abstract Limited data are available for clinical characteristics of patients with coronavirus disease 2019 (COVID-19) outside Wuhan. This study aimed to describe the clinical characteristics of COVID-19 and identify the risk factors for severe illness of COVID-19 in Jiangsu province, China. Clinical data of hospitalized COVID-19 patients were retrospectively collected in 8 hospitals from 8 cities of Jiangsu province, China. Clinical findings of COVID-19 patients were described and risk factors for severe illness of COVID-19 were analyzed. By Feb 10, 2020, 202 hospitalized patients with COVID-19 were enrolled. The median age of patients was 44.0 years (interquartile range, 33.0–54.0). 55 (27.2%) patients had comorbidities. At the onset of illness, the common symptoms were fever (156 [77.2%]) and cough (120 [59.4%]). 66 (32.7%) patients had lymphopenia. 193 (95.5%) patients had abnormal radiological findings. 11 (5.4%) patients were admitted to the intensive care unit and none of the patients died. 23 (11.4%) patients had severe illness. Severe illness of COVID-19 was independently associated with body mass index (BMI) ≥ 28 kg/m2 (odds ratio [OR], 9.219; 95% confidence interval [CI], 2.731 to 31.126; P<0.001) and a known history of type 2 diabetes (OR, 4.326; 95% CI, 1.059 to 17.668; P = 0.041). In this case series in Jiangsu Province, COVID-19 patients had less severe symptoms and had better outcomes than the initial COVID-19 patients in Wuhan. The BMI ≥ 28 kg/m2 and a known history of type 2 diabetes were independent risk factors of severe illness in patients with COVID-19. Short Title Clinical findings of patients with coronavirus disease 2019 in Jiangsu province, China