Pre-existing immunity to SARS-CoV-2: the knowns and unknowns

Type Journal Article Author Alessandro Sette Author Shane Crotty URL https://www.nature.com/articles/s41577-020-0389-z Rights 2020 Springer Nature Limited Series Comment Volume 20 Issue 8 Pages 457-458 Publication Nature Reviews Immunology ISSN 1474-1741 Date 07/07/2020 Extra Number: 8 Publisher: Nature Publishing Group DOI 10.1038/s41577-020-0389-z Library Catalog www.nature.com Language en Abstract T cell reactivity against SARS-CoV-2 was observed in unexposed people; however, the source and clinical relevance of the reactivity remains unknown. It is speculated that this reflects T cell memory to circulating ‘common cold’ coronaviruses. It will be important to define specificities of these T cells and assess their association with COVID-19 disease severity and vaccine responses. Short Title Pre-existing immunity to SARS-CoV-2