Prognostic impact of early versus delayed loop diuretic administration in sepsis: a propensity score-matched analysis using the MIMIC-IV database

CONCLUSIONS: While complete adjustment for all potential confounding factors was not possible, the findings suggest that patients who received loop diuretics within 48 hours had more severe kidney injury and a significantly higher mortality rate compared to those who received later administration (after 96 hours). These findings underscore the need for careful consideration when determining the timing of loop diuretic initiation in clinical practice.