The Prevalence and Characteristics of Infective Endocarditis in Liver Transplant Recipients: Insights From National Inpatient Sample Database

Clin Cardiol. 2025 Apr;48(4):e70130. doi: 10.1002/clc.70130.

ABSTRACT

BACKGROUND: Liver transplant (LT) recipients are immunocompromised and thus predisposed to various bacterial and fungal infections, including infective endocarditis (IE). The current paper aims to determine the prevalence, characteristics, and outcomes of IE in LT recipients.

METHODS: The National Inpatient Sample (NIS) data from 2016 to 2020 was used to identify LT recipients. Patients were separated into two groups based on the presence of IE. Information was collected on patient demographics, hospital characteristics, infections, comorbidities, and outcomes. Multivariate logistic regression was performed to assess the impact of IE on outcomes after adjusting for confounding factors.

RESULTS: A total of 170 650 patients who underwent LT were identified using NIS data from 2016 to 2020, of which 0.003% had IE. IE group had higher odds of in-hospital mortality [aOR 2.2 (95% CI 1.07-4.78)], Shock [aOR 2.7 (95% CI 1.61-4.65)], ICU admission [aOR 2.40 (95% CI 1.4-4.2)], longer Length of Stay [adj. Coeff- 3.4 days (95% CI -0.89-5.9, p < 0.008)], and higher hospitalization charges (adj. coeff-$65271.52, 95% CI $14 825-$115 718) than LT without IE group.

CONCLUSION: Staphylococcus was present in 18.6% of IE in LT, followed by enterococcus (12.8%) and gram-negative bacteria (9.8%). Concomitant IE was associated with increased in-hospital death, ICU stay, and shock. The IE group was also associated with increased LOS and total charges compared to the LT without IE. Although the prevalence of IE is low in LT recipients, its presence portends worse outcomes.

PMID:40223671 | PMC:PMC11995030 | DOI:10.1002/clc.70130