Comprehensive screening of potential inhibitors from ZINC15 database for Metallo-L1 beta -Lactamase from Stenotrophomonas maltophilia via in Silico and in vitro approaches

CONCLUSION: The study validates a promising compound for overcoming resistance caused by L1 β-lactamase in Stenotrophomonas maltiphilia. These results highlight the potential of combining computational and experimental approaches to develop novel therapies. The findings provide a foundation for future strategies targeting β-lactamase-mediated resistance in Stenotrophomonas maltophilia.