Summary:
Adjuvants are immunostimulators used to enhance vaccine efficacy against infectious diseases. However, current methods for evaluating their efficacy and safety are limited, hindering large-scale screening. To address this, we developed a prototype Adjuvant Database (ADB) containing transcriptome data, generated using the same protocols as the widely used Open TG-GATEs (OTG) toxicogenomics database, covering 25 adjuvants across multiple species, organs, time points, and doses. This enabled...
Link:
https://pubmed.ncbi.nlm.nih.gov/40795871/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=12QQbiNmM99eUQGIX1JjHIKcROC1Vzv4sOS-2S_LNI19uG_Yrk&fc=20220129225649&ff=20250818213523&v=2.18.0.post9+e462414
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Authors:
Yayoi Natsume-Kitatani, Kouji Kobiyama, Yoshinobu Igarashi, Taiki Aoshi, Noriyuki Nakatsu, Lokesh P Tripathi, Junichi Ito, Johan Nyström-Persson, Yuji Kosugi, Rodolfo S Allendes Osorio, Chioko Nagao, Burcu Temizoz, Etsushi Kuroda, Daron M Standley, Hiroshi Kiyono, Kenji Nakanishi, Satoshi Uematsu, Isao Hamaguchi, Yasuhiro Yasutomi, Jun Kunisawa, Sho Yamasaki, Cevayir Coban, Hiroshi Yamada, Kenji Mizuguchi, Ken J Ishii
Date tagged:
08/18/2025, 21:35
Date published:
08/12/2025, 06:00