Using the Reactome Graph Database to generate pathway fingerprints for cancer-related genes, and using the fingerprints to gain insights into cancer, comorbidity, and cancer gene networks

The Reactome Graph Database, which describes biological processes in 28 top-level pathways and facilitates efficient data- traversal and retrieval, has been used in a novel way to generate pathway fingerprints for 862 cancer driver- and 324 comorbidity-associated- genes; the latter set of genes cause Mendelian Diseases (MDs) which are comorbid with cancer. A pathway fingerprint presents pathway information about a gene in a novel way. It lists all pathways in which the gene participates,...