Association between vasoactive drug use and 28-day in-hospital mortality in patients with septic shock in the intensive care unit: A retrospective study based on the MIMIC-IV database

Septic shock, a life-threatening intensive care unit condition characterized by persistent hypotension and organ dysfunction despite fluid resuscitation, is a leading cause of intensive care unit mortality. Vasoactive drugs are central to hemodynamic support in septic shock but their benefit-potential adverse event trade-off remains controversial; existing studies link high-dose vasopressors to increased mortality, though the association with 28-day mortality is unclear due to limitations like...