Bibliometric analysis of sugammadex sodium literature based on the Web of Science database

Medicine (Baltimore). 2025 Dec 5;104(49):e46464. doi: 10.1097/MD.0000000000046464.

ABSTRACT

OBJECTIVE: This study employed bibliometric techniques to conduct both qualitative and quantitative analyses of literature pertaining to sugammadex sodium. The aim was to uncover the trends and hotspots of research in this field.

METHODS: Publications on sugammadex sodium published from January 2002 to December 2024 were extracted from the Web of Science Core Collection. Statistical analysis and visualization of publication data were performed using CiteSpace, Bibliometrix, and Excel.

RESULTS: A total of 1006 articles were analyzed, including 3922 researchers from 56 countries/regions and 933 institutions. These studies have been published in 305 journals. Although Dutch scholars have demonstrated greater influence, the United States boasted the highest output. Among these institutions, Merck Germany had the highest publication volume and impact. Dutch researcher De Boer HD ranked the highest in terms of publication volume and influence. The British Journal of Anesthesia was the leading journal in terms of publications on sugammadex sodium, with a total of 59 articles. The most cited article in the field was by Kheterpal and colleagues, published in Anesthesiology in 2020. Keyword analysis revealed frequent comparisons of sugammadex sodium and neostigmine. Research hotspots have primarily focused on the reversal of rocuronium-induced neuromuscular blockade, deep neuromuscular blockade reversal, impact on residual neuromuscular blockade, and postoperative complications. The effects of sugammadex sodium on postoperative complications, particularly pulmonary complications, represent a current research frontier.

CONCLUSION: Research on sugammadex sodium has received significant scholarly attention, with strong potential for future collaborative studies. The impact of sugammadex sodium on postoperative complications remains a promising area for in-depth analysis and a topic for future research.

PMID:41366985 | PMC:PMC12689006 | DOI:10.1097/MD.0000000000046464