Impact of prior cancer history on survival in patients with adenocarcinoma of esophagogastric junction: a retrospective cohort study using SEER database

CONCLUSIONS: While prior cancer history adversely impacts overall survival in AEG patients, specific subgroups-particularly those with select cancer types-exhibit comparable outcomes. These findings suggest that current exclusion criteria may be overly restrictive, and support refining trial eligibility to include well-selected prior-cancer patients.