Clinical predictors of overall survival in very elderly patients with spinal osteosarcoma: an analysis of the surveillance, epidemiology, and end results database

CONCLUSION: Both STR and GTR improve overall survival in patients ≥75 years of age, with persisting benefits after adjustment for tumor grade. Chemotherapy and radiotherapy demonstrated additional survival advantages in the very elderly when grade was considered. These findings highlight treatment feasibility and multimodal therapy as more critical than histologic grade in guiding decisions.