Pharmacovigilance analysis of severe cutaneous adverse reactions associated with antiseizure medications: a FAERS database study with time-to-onset evaluation

CONCLUSION: ASM-associated SCARs are predominantly concentrated in SJS and TEN and show substantial heterogeneity across individual drugs. Most events occur early after treatment initiation, particularly within the first month, indicating an early period of reporting concentration after ASM initiation. These findings provide hypothesis-generating pharmacovigilance evidence regarding the reporting patterns and time-to-onset characteristics of ASM-associated SCARs and may help inform future risk...