Binding affinities for histamine receptors 1 to 4: Systematic comparison of ligands from the Psychoactive Drug Screening Program K(i) database and International Union of Basic and Clinical Pharmacology/British Pharmacological Society Guide to Pharmacology
database[Title] 2026-07-08
Summary:
Histamine receptors (H(1)R-H(4)R) are G protein-coupled receptors with large physiological and therapeutic relevance. Despite extensive research, a systematic and cross-database overview of ligands is missing. This review integrates the Psychoactive Drug Screening Program (PDSP) K(i) database and the International Union of Basic and Clinical Pharmacology/British Pharmacological Society (IUPHAR/BPS) Guide to Pharmacology, both having different scopes and curation principles, and evaluates...