DFBP: A Comprehensive Database of Food-Derived Bioactive Peptides for Peptidomics Research

Bioinformatics. 2022 May 13:btac323. doi: 10.1093/bioinformatics/btac323. Online ahead of print.

ABSTRACT

MOTIVATION: Food-derived bioactive peptides (FBPs) have demonstrated their significance in pharmaceuticals, diets, and nutraceuticals, benefiting public health and global ecology. While significant efforts have been made to discover FBPs and to elucidate the underlying bioactivity mechanisms, there is lack of a systemic study of sequence-structure-activity relationship of FBPs in a large dataset.

RESULTS: Here, we construct a database of food-derived bioactive peptides (DFBP), containing a total of 6276 peptide entries in 31 types from different sources. Further, we develop a series of analysis tools for function discovery/repurposing, traceability, multifunctional bioactive exploration, and physiochemical property assessment of peptides. Finally, we apply this database and data-mining techniques to discover new FBPs as potential drugs for cardiovascular diseases. The DFBP serves as a useful platform for not only the fundamental understanding of sequence-structure-activity of FBPs, but also the design, discovery, and repurposing of peptide-based drugs, vaccines, materials, and food ingredients.

AVAILABILITY AND IMPLEMENTATION: DFBP service can be accessed freely via http://www.cqudfbp.net/.

SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.

PMID:35552640 | DOI:10.1093/bioinformatics/btac323