CYTOCON: The manually curated database of human in vivo cell and molecule concentrations

CPT Pharmacometrics Syst Pharmacol. 2022 Sep 21. doi: 10.1002/psp4.12867. Online ahead of print.

ABSTRACT

CYTOCON DB¹ (Cell and cYTOkine CONcentrations DataBase) is a project undertaken by the InSysBio team and aimed at the development of a database that allows collecting, processing and visualizing publicly available in vivo human data on baseline concentrations of cells, cytokines, chemokines and other molecules. Besides manual curation, an important feature of CYTOCON is that most values found in papers are converted from a huge variety of original units (i.e., mg/mL, number of cells per mm² of biopsy surface section) to unified units: "pM" for cytokine and "kcell/L" for cell concentration. These features of the database can help researchers facilitate the creation and calibration of QSP models. Possible applications can be: estimation of the average value or variability of the cell, cytokine or chemokine concentrations for patient groups with different characteristics, such as age, gender, disease severity, disease subtype, etc.; analysis of correlations between the cell, cytokine or chemokine concentrations in patients with different characteristics, such as severity of the disease.

PMID:36128761 | DOI:10.1002/psp4.12867