Epidemiology conduction of paediatric rheumatic diseases based on the registry database of the Pediatric Rheumatology Association of Japan

Mod Rheumatol. 2022 Sep 16:roac112. doi: 10.1093/mr/roac112. Online ahead of print.

ABSTRACT

OBJECTIVES: Although epidemiological surveys of paediatric rheumatic diseases in Japan have been conducted they were single surveys with no continuity. This is the first report of the Pediatric Rheumatology Association of Japan (PRAJ) registry database, which was established to continuously collect data for paediatric rheumatic diseases.

METHODS: 'PRICUREv2' (Pediatric Rheumatology International Collaborate Unit Registry version 2) is a registry database established by the PRAJ. The registry data were analysed for the age of onset, time to diagnosis, sex differences, seasonality, and other factors.

RESULTS: Our data showed the same trend regarding rates of paediatric rheumatic diseases reported in Japan and other countries. The age of onset was lower in juvenile idiopathic arthritis (JIA) and juvenile dermatomyositis (JDM) and higher in systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS). The time to diagnosis was relatively short in JIA and SLE but longer in JDM and SS. Rheumatoid factor-positive polyarticular JIA showed a seasonality cluster with regard to onset.

CONCLUSION: PRICUREv2 aided the retrieval and evaluation of current epidemiological information on patients with paediatric rheumatic diseases. It is expected that the data collection will be continued and will be useful for expanding research in Japan.

PMID:36112493 | DOI:10.1093/mr/roac112