RegulonDB v12.0: a comprehensive resource of transcriptional regulation in E. coli K-12

Nucleic Acids Res. 2024 Jan 5;52(D1):D255-D264. doi: 10.1093/nar/gkad1072.

ABSTRACT

RegulonDB is a database that contains the most comprehensive corpus of knowledge of the regulation of transcription initiation of Escherichia coli K-12, including data from both classical molecular biology and high-throughput methodologies. Here, we describe biological advances since our last NAR paper of 2019. We explain the changes to satisfy FAIR requirements. We also present a full reconstruction of the RegulonDB computational infrastructure, which has significantly improved data storage, retrieval and accessibility and thus supports a more intuitive and user-friendly experience. The integration of graphical tools provides clear visual representations of genetic regulation data, facilitating data interpretation and knowledge integration. RegulonDB version 12.0 can be accessed at https://regulondb.ccg.unam.mx.

PMID:37971353 | PMC:PMC10767902 | DOI:10.1093/nar/gkad1072