HSCGD: a comprehensive database of single-cell whole-genome data and metadata

Nucleic Acids Res. 2024 Oct 29:gkae971. doi: 10.1093/nar/gkae971. Online ahead of print.

ABSTRACT

Single-cell whole-genome sequencing is a powerful tool for uncovering mutations in individual cells. In recent times, the generation of vast amounts of data has significantly advanced our understanding of key biological processes, including cell development and tumor progression. This rapid accumulation of data underscores the urgent need for a comprehensive resource platform to manage and utilize this information effectively. To address this need, we introduce HSCGD, the first open-access and comprehensive database dedicated to the collection, integration, analysis, and visualization of single-cell whole-genome data and metadata. The current release of HSCGD includes processed single-cell whole-genome sequencing data and curated metadata of 74 154 human cells derived from 63 public single-cell datasets, involving 23 cell types and 17 major single-cell whole-genome amplification methods. HSCGD is designed to help researchers interested in cellular heterogeneity explore and utilize whole genome data at the single-cell level by providing browsing, searching, visualization, downloading and online tools. The database can be accessed from the following URL: http://www.hscgd.com.

PMID:39470706 | DOI:10.1093/nar/gkae971