CVD Atlas: a multi-omics database of cardiovascular disease

Nucleic Acids Res. 2024 Oct 1:gkae848. doi: 10.1093/nar/gkae848. Online ahead of print.

ABSTRACT

Cardiovascular disease (CVD) is the leading cause of illness and death worldwide. Numerous studies have been conducted into the underlying mechanisms and molecular characteristics of CVD using various omics approaches. However, there is still a need for comprehensive resources on CVD. To fill this gap, we present the CVD Atlas, accessed at https://ngdc.cncb.ac.cn/cvd. This database compiles knowledge and information from manual curation, large-scale data analysis, and existing databases, utilizing multi-omics data to understand CVDs comprehensively. The current version of CVD Atlas contains 215,333 associations gathered from 308 publications, 652 datasets and 7 databases. It covers 190 diseases and 44 traits across multiple omics levels. Additionally, it provides an interactive knowledge graph that integrates disease-gene associations and two types of analysis tools, offering an engaging way to query and display relationships. CVD Atlas also features a user-friendly web interface that allows users to easily browse, search, and download all association information, research metadata, and annotation details. In conclusion, CVD Atlas is a valuable resource that enhances the accessibility and utility of knowledge and information related to CVD, benefiting human health and CVD research communities.

PMID:39351894 | DOI:10.1093/nar/gkae848