BitterDB: 2024 update on bitter ligands and taste receptors

BitterDB (http://bitterdb.agri.huji.ac.il) was introduced in 2012 as a central resource for information on bitter-tasting molecules and their receptors, and was updated in 2019. The information in BitterDB is used for tasks such as exploring the bitter chemical space, choosing suitable ligands for experimental studies, analyzing receptors' selectivity and promiscuity, and developing machine learning predictors for taste. Here, we describe a major upgrade of the database, including significant...