VFDB 2025: an integrated resource for exploring anti-virulence compounds
(database[TitleAbstract]) AND (Nucleic acids research[Journal]) 2024-11-14
Summary:
With the escalating crisis of bacterial multidrug resistance, anti-virulence therapeutic strategies have emerged as a highly promising alternative to conventional antibiotic treatments. Anti-virulence compounds are specifically designed to target virulence factors (VFs), disarming pathogens without affecting bacterial growth and thus reduce the selective pressure for resistance development. However, due to the complexity of bacterial pathogenesis, no anti-virulence small molecules have been...