SHARK: web server for alignment-free homology assessment for intrinsically disordered and unalignable protein regions

(database[TitleAbstract]) AND (Nucleic acids research[Journal]) 2025-06-07

Summary:

Whereas alignment has been fundamental to sequence-based assessments of protein homology, it is ineffective for intrinsically disordered regions (IDRs) due to their lowered sequence conservation and unique sequence properties. Here, we present a web server implementation of SHARK (bio-shark.org), an alignment-free algorithm for homology classification that compares the overall amino acid composition and short regions (k-mers) shared between sequences (SHARK-scores). The output of such...

Link:

https://pubmed.ncbi.nlm.nih.gov/40396357/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1VsHRGSo3HX0CgC40wRgBdaScQKv8CRE2sO_GaWJzhPEXTSQfX&fc=20220129230418&ff=20250607060523&v=2.18.0.post9+e462414

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📚BioDBS Bibliography » (database[TitleAbstract]) AND (Nucleic acids research[Journal])

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Authors:

Chi Fung Willis Chow, Maxim Scheremetjew, HongKee Moon, Soumyadeep Ghosh, Anna Hadarovich, Lena Hersemann, Agnes Toth-Petroczy

Date tagged:

06/07/2025, 06:05

Date published:

05/21/2025, 06:00