ASTRA: a comprehensive resource of stress-induced transcriptional activity in human cell lines
(database[TitleAbstract]) AND (Nucleic acids research[Journal]) 2025-12-10
Summary:
The atlas of stress response activity (ASTRA) is an open-access, curated database cataloging transcriptomic responses to stress in human cell lines, organized by major stress categories to advance research on conserved and stress-specific pathways, RNA biomarkers, and disease mechanisms. It integrates and standardizes bulk RNA-seq datasets from the Gene Expression Omnibus (GEO), focusing on messenger RNA and long noncoding RNA expression under diverse stress conditions. Data are grouped into...