DynaRepo: the repository of macromolecular conformational dynamics
(database[TitleAbstract]) AND (Nucleic acids research[Journal]) 2025-12-10
Summary:
Proteins, RNA, and DNA are central to virtually all cellular processes, often assembling into macromolecular complexes to perform their functions. While these molecules are inherently dynamic, most methods for studying their mechanisms focus on static structures. Recent deep learning advances in protein structure prediction highlight the potential of data-driven approaches, yet dynamic behavior that is critical for interactions such as antibody-antigen recognition, intrinsically disordered...