MGDB: a curated database for molecular glues

Molecular glues (MGs) represent a unique class of small molecules that modulate protein-protein interactions by altering target protein surface properties, enabling targeted degradation, pathway modulation, or functional control of proteins, including traditionally undruggable targets. Currently, 17 MG-based drugs are approved globally with over 40 in clinical trials, underscoring their therapeutic potential. Despite these advances, the lack of a dedicated database integrating structural,...