connectomeDB2025: a rigorously curated, multi-species resource of experimentally supported ligand-receptor interactions

Inferring cell-cell communication networks is now a cornerstone of single-cell RNA-seq and spatial transcriptomics data analysis, relying critically on reference catalogues of experimentally supported ligand-receptor interactions. Here, we present the updated, rigorously curated connectomeDB, an open-access database of peptide-based ligand-receptor pairs comprising 3579 vertebrate interactions supported by primary experimental evidence from 2803 research articles. By critically reviewing all...