Spatial GWAS Atlas: a knowledgebase for decoding the genetic architecture of complex traits in spatial resolution

Genome-wide association studies (GWAS) have identified a large number of variants linked to complex traits and diseases, most of which lie in noncoding regions and act in a tissue- and cell type-specific manner. However, how these genetic effects are distributed within the spatial architecture of tissues remains poorly understood. Spatial transcriptomics (ST) profiles gene expression while preserving spatial coordinates, offering a powerful way to localize genetic effects within tissue...