PolyA_DB v4: systematic polyA site identification and isoform annotation in human and mouse genomes using 3' end and long-read sequencing data

The cleavage and polyadenylation site (PAS) defines the 3' end of almost all protein-coding and long non-coding RNAs in eukaryotes. Most genes harbor multiple PAS, resulting in expression of alternative polyadenylation (APA) isoforms. Here, we present PolyA_DB version 4 (https://exon.apps.wistar.org/polya_db/v4/), an updated database dedicated to PAS in mammalian genomes. By exhaustive mining of human and mouse transcriptomic data sets generated by the 3' region extraction and deep sequencing...